发明名称 |
ANTIVIRAL ACTIVITY AND RESOLUTION OF 2-HYDROXYMETHYL-5-(5-FLUOROCYTOSIN-1-YL)-1,3-OXATHIOLANE |
摘要 |
A method and composition for the treatment of HIV and HBV infections in humans is disclosed that includes administering an effective amount of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3- oxathiolane, a pharmaceutically acceptable derivative thereof, including a 5' or N4 alkylated or acylated derivative, or a pharmaceutically acceptable salt thereof, in a pharmaceutically acceptable carrier. A process fot the resolution of a racemic mixture of nucleoside enantiomers is also disclosed that includes the step of exposing the racemic mixture to an enzyme that preferentially catalyzes a reaction in one of the enantiomers. |
申请公布号 |
CA2513440(C) |
申请公布日期 |
2010.11.30 |
申请号 |
CA19922513440 |
申请日期 |
1992.02.20 |
申请人 |
EMORY UNIVERSITY |
发明人 |
LIOTTA, DENNIS C.;SCHINAZI, RAYMOND F.;CHOI, WOO-BAEG |
分类号 |
C07D411/04;A61K31/506;C07H19/06;C12P41/00 |
主分类号 |
C07D411/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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