发明名称 |
USE OF ANTAGONIST ANTI-CD40 ANTIBODIES FOR TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA |
摘要 |
Methods of therapy for treating a subject for an autoimmune disease and/or inflammatory disease are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a patient in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity, but exhibits antagonist activity when the antibody binds a CD40 antigen on a human CD40-expressing cell. Antagonist activity of the anti-CD40 antibody or antigen-binding fragment thereof beneficially inhibits CD40L-mediated stimulation of CD40-expressing cells, and thus inhibits survival and signaling pathways of human CD40-expressing cells that are mediated by CD40L.
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申请公布号 |
PT1682177(E) |
申请公布日期 |
2010.11.29 |
申请号 |
PT20040810417T |
申请日期 |
2004.11.04 |
申请人 |
XOMA TECHNOLOGY LT.;NOVARTIS VACCINES AND DIAGNOSTICS, INC. |
发明人 |
LI LONG;MOHAMMAD LUQMAN;ASHA YABANNAVAR;SHARON LEA AUKERMAN |
分类号 |
A61K39/395;C07K16/28 |
主分类号 |
A61K39/395 |
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