| 摘要 |
FIELD: medicine. ^ SUBSTANCE: invention refers to medicine, namely to oncology. The compound- conjugate antibody-medicinal agent is proposed with formula I: Ab-(L-D)p, where one or more molecules of maytanazoid medicinal agents (D) are covalently binded by L to the antibody huMAb4D5-8 (Trastuzumab) (Ab), which binds to the HER2 receptor and inhibits tumor cell growth, overexpressing HER2 receptor. ^ EFFECT: also a pharmaceutical composition is proposed which contains the specified compound, and a method of treating malignant tumor using this composition. ^ 20 cl, 8 tbl, 10 ex, 17 dwg |
