| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention relates to a method for synthesis of derivatives in the family of pyrrole[3,4-c]carbazole, and specifically to a method for synthesis of novel 2-R1-6-R2-5-aryl-pyrrole[3,4-c]carbazole-1,3(2H,6H)-diones of formula I: , where R1=:C1-C6 alkylphenyl, C1-C6 dialkylphenyl, C1-C6 dialkylphenyl dioxy C1-C6 alkyl; R2=C1-C6 alkyl; Ar=phenyl, C1-C6 alkyl phenyl, oxyalkylphenyl, halophenyl, having potential anticancer activity. The method involves reacting 1-R2-indolin-2-ones of general formula II with oxalyl chloride and 4-aryl-3-butenoic acid of general formula III, reacting the formed 3-(2-chloro-1-R2-1H-indol-3-yl)-4-[(E)-2-arylethenyl]furan-2,5-diones of general formula IV with R1-amines of general formula R1-NH2 V, and then photocyclisation of the formed 1-alkyl-3-(2-chloro-1-R2 -1H-indol-3-yl)-4-[(E)-2-arylethenyl]-1H-pyrrole-2,5-diones of general formula VI, where R1, R2 and Ar assume values listed above. ^ EFFECT: method for synthesis of novel derivatives having potential anticancer activity. |
