Diagnosis and prognosis of infectious disease clinical phenotypes and other physiologic states using host gene expression biomarkers in blood

摘要

Disclosed is a method for identifying gene expression markers for distinguishing between healthy, febrile and convalescent subjects that have been exposed to one or more infectious pathogens. The method is as disclosed in the complete specification and involves: a) acquiring a gene expression profile for a subject that has been exposed to one or more infectious pathogens; b) acquiring a gene expression profile for a subject that has recovered from exposure to said one or more infectious pathogens; c) acquiring a gene expression profile for a healthy subject that has not been exposed to said one or more infectious pathogens; d) comparing the gene expression profiles for the subjects from a), b) and c) by a pairwise comparison; and e) determining the identity of a nested minimal set(s) of genes that classify the subject as healthy, febrile, or convalescent by class prediction algorithm based on said pair wise comparison.