Treatment of Clostridium difficile infections with antibodies directed against Acetyl-CoA acetyltransferase

摘要

Disclosed are antibodies specific for the conserved peptide epitope, Val Val Ile Ala, from the acetyl-CoA acetyltransferase (acetyl-CoA thiolase) from Clostridium difficile. The antibodies are claimed for use in the treatment and prophylaxis of C. difficile infection, with the treatment also comprising an antibiotic from the group: gentamicin, vancomycin and metronidazole. The treatment can be used against vancomycin resistant C. difficile as well as Enterococcus faecium or E. faecalis.