| 摘要 |
Disclosed is a 4-[3-fluoro-5-(methylsulfoynl)phenyl]piperidine derivative of formula (1), or a pharmaceutically selected salt thereof, wherein R is selected from C1-3alkyl and allyl. Also disclosed is the use of the compound to treat disorders of the central nervous system, such as Parkinson's disease, Parkinsonism, dyskinesias (including LDOPA induced dyskinesias), dystonias, tics, tremor, Huntington disease, iatrogenic and non-iatrogenic psychoses and hallucinoses, schizophrenia and schizophreniform disorders, bipolar disorder, mood and anxiety disorders, depression, obsessive-compulsive disease, neurodevelopmental disorders selected from Autism spectrum disorders, ADHD, Cerebral Palsy, Gilles de la Tourette's syndrome, dementia, age-related cognitive impairment, sleep disorders, sexual disorders, eating disorders, obesitas, headaches and other pains in conditions characterized by increased muscular tone, improvement of motor functions, cognitive functions and related emotional disturbances, and after brain injury induced by traumatic, inflammatory, infectious, neoplastic, vascular, hypoxic or metabolic causes or brain injury induced by toxic reactions to exogenous chemicals such as substances of abuse, pharmaceutical compounds, environmental toxins, a disorder related to substance abuse, Alzheimer's disease or related dementia disorders.
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