| 摘要 |
Provided is a screening method being able to screen an agent useful for prevention and/or treatment of hepatitis C virus-related disease easily and efficiently and a prophylactic and/or therapeutic agent for hepatitis C virus-related disease obtained by the method. The screening method for a prophylactic and/or therapeutic agent for hepatitis C virus-related disease according to the present invention is characterized by comprising a a step of examining the inhibitory activity of an test substance on the protein-protein interaction between hepatitis C virus core protein and PA28γ. The method can be carried out, for example, by using transcriptional activity of a lipid metabolism-control factor as indicator. The test substance used in the method may have an activity to inhibit expression or function of the PA28γ gene. The hepatitis C virus-related diseases include hepatitis C, fatty liver, acute hepatitis, chronic hepatitis, liver cirrhosis, liver cancer, insulin-resistant diseases, and the like. The method according to the present invention is extremely useful as a method of obtaining an agent superior in preventive and therapeutic activity particularly to diseases such as fatty liver and liver cancer.
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