| 摘要 |
<p>An attention is focused on a branched structure of a core sugar chain of LOS produced by meningitis-inducing bacteria (Neisseria bacteria), and a tool which enables the diagnosis of meningitis by utilizing not the entire structure of the sugar chain but a partial structure of the core sugar chain is provided. In deacylated LOS, a functional group such as a phosphate group and an acetyl group expressed in the core sugar chain is also removed, and therefore deacylated LOS cannot be utilized for detecting a bacterium capable of producing the core sugar chain containing such a functional group. Thus, also provided is a diagnosis tool which is free of the concerns for those constraints. Further disclosed is a vaccine against meningitis-inducing bacteria (Neisseria bacteria), which is prepared utilizing a partial structure of the core sugar chain without carrying out deacylation. The vaccine utilizes at least one (e.g., several) partial sugar chain containing the core sugar chain, and is a vaccine which is developed based on an innovative idea so as to deal with the mutation of meningitis-inducing bacteria (Neisseria bacteria).</p> |
