发明名称 |
Polysaccharide-protein conjugate vaccines |
摘要 |
Methods for synthesis and manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group on one reactant with an aldehyde or cyanate ester group on the other reactant. The reaction proceeds rapidly with a high conjugation efficiency, such that a simplified purification process can be employed to separate the conjugate product from the unconjugated protein and polysaccharide and other small molecule by-products. |
申请公布号 |
AU2004263135(B2) |
申请公布日期 |
2010.11.25 |
申请号 |
AU20040263135 |
申请日期 |
2004.08.06 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
CARL E. FRASCH;CHE-HUNG ROBERT LEE |
分类号 |
A61K39/02;A61K39/09;A61K39/095;A61K39/102;A61K39/112;A61K39/385;A61K47/48 |
主分类号 |
A61K39/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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