SUBSTITUTED 8-SULFONYL-2,3,4,5-TETRAHYDRO-1H-GAMMA-CARBOLINES, LIGANDS AND PHARMACEUTICAL COMPOSITION; METHOD FOR THE PRODUCTION AND USE OF SAME

摘要

The invention relates to substituted 8-sulfonyl-2,3,4,5-tetrahydro-1H-?-carbolines of general formula 1 and pharmaceutically acceptable salts and ligands thereof which exhibit biological activity with respect to alpha-adrenoceptors, dopamine receptors, histamine receptors, imidazoline receptors, sigma receptors, norepinephrine receptors and serotonin receptors simultaneously, as well as to active ingredients and pharmaceutical compositions containing the new ligands as active ingredient and to new drugs that can be used to treat diseases and conditions of the central nervous system. In general formula 1, R1 is a substituent selected from hydrogen, optionally substituted C1-C3 alkyl or C1-C4 alkoxycarbonyl; R2 is a cyclic system substituent, inter alia a hydrogen atom, optionally substituted C1-C3 alkyl, optionally substituted C2-C3 alkenyl or substituted sulfonyl; and R3 is optionally substituted aryl or a substituted amino group.