发明名称 |
MYCOBACTERIAL MUTANTS AFFECTING HOST APOPTOSIS |
摘要 |
Provided are recombinant mycobacteria having a mutation in an nlaA gene or in a nuoG gene. Also provided are isolated and purified nlaA proteins and nuoG proteins from a mycobacterium. Additionally provided are isolated and purified nucleic acids comprising a recombinant nlaA gene or a recombinant nuoG gene. Further provided are methods of inducing an immune response in a mammal and methods of making a recombinant mycobacterium using the nlaA gene or the nuoG gene.
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申请公布号 |
US2010297185(A1) |
申请公布日期 |
2010.11.25 |
申请号 |
US20060794506 |
申请日期 |
2006.01.12 |
申请人 |
ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY |
发明人 |
JACOBS, JR. WILLIAM R.;PORCELLI STEVEN A.;BRIKEN VOLKER;BRAUNSTEIN MIRIAM |
分类号 |
A61K39/04;A61P37/04;C12N1/20;C12N15/00 |
主分类号 |
A61K39/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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