COMBINED CHEMICAL AND GENETIC APPROACHES FOR GENERATION OF INDUCED PLURIPOTENT STEM CELLS.

摘要

The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency. The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency. A discontinuous drive power tool assembly for generating rotational torque. The tool assembly includes a spindle having a first end portion configured to receive a socket. The first end portion has a primary engaging surface and a tapered surface spaced from a distal end of the first end portion. The primary engaging surface and the tapered surface are configured to engage corresponding surfaces on the socket. The tool assembly also includes a pulse hammer engagable with a second end portion of the spindle that is opposite the first end portion, and a motor including a motor shaft engagable with the pulse hammer, the motor being configured to rotate the pulse hammer.