发明名称 |
PROTECTIVE ANTI-GLUCAN ANTIBODIES WITH PREFERENCE FOR BETA-1,3-GLUCANS |
摘要 |
Anti-&bgr;-1,3-glucan antibodies have been found to be protective against systemic fungal infection with Candida albicans. The present invention provides monoclonal antibodies that bind to &bgr;-1,3-glucan, hybridoma cell lines producing the antibodies, compositions comprising the antibodies and methods of using such antibodies for treatment of microbial infections, particularly against Candida albicans and Aspergillus fumigatis infections. The antibodies of the present invention are not specific for (&bgr;-1,6-glucan.
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申请公布号 |
US2010297130(A1) |
申请公布日期 |
2010.11.25 |
申请号 |
US20100851962 |
申请日期 |
2010.08.06 |
申请人 |
NOVARTIS VACCINES AND DIAGNOSTICS, INC. |
发明人 |
CASSONE ANTONIO;TOROSANTUCCI ANTONELLA |
分类号 |
A61K39/395;A61P31/00;A61P31/04;A61P31/06;A61P31/10;A61P33/02;A61P33/04;C07H21/04;C07K16/00;C07K16/12;C07K16/14;C12N5/071;C12N5/24;C12N15/63 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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