PROCESS FOR PREPARATION OF TAZAROTENE

摘要

Disclosed herein is process fro preparation of 6-(2-(4,4-dimethylthiochroman-6- yl)ethynyl)nicotinate known as Tazarotene of Formula 1 and its pharmaceitical acceptable salts, wherein said process comprises, reacting 4,4-dimethyl-6-acethylthiochroman with chlorinating reagent to get novel intermediate compound 6-(1,1-dichloroethyl)-4,4- dimethylthiochroman followed by converting the compound 6-(1,1-dichloroethyl)-4,4- dimethylthiochroman to get Tazarotene.