发明名称 ETOMIDATE ANALOGUES WITH IMPROVED PHARMACOKINETIC AND PHARMACODYNAMIC PROPERTIES.
摘要 <p>The invention is directed to compounds according to formula (I): where R1 is L1C(O)OT or L1C(O)OL2C(O)OT; R2 is a substituted or unsubstituted C1-C10 alkyl, C2-C10 alkenyl, or C2-C10 alkynyl, or R1; n is an integer from 0 to 5; each R3 is independently halogen or R2; L1 and L2 are each independently a bond, a substituted or unsubstituted C1-C10 alkylene, C2-C10 alkenylene, or C2-C10 alkynylene; and T is H, a substituted or unsubstituted C1-C10 alkyl, C2-C10 alkenyl, or C2-C10 alkynyl, nitrophenol, or cyclopropyl. The invention is also directed to a pharmaceutical composition comprising a compound according to formula (I) and a pharmaceutically acceptable carrier, and to methods for providing anesthesia in mammals by administering such a pharmaceutical composition.</p>
申请公布号 MX2010010675(A) 申请公布日期 2010.11.25
申请号 MX20100010675 申请日期 2009.03.31
申请人 THE GENERAL HOSPITAL CORPORATION. 发明人 DOUGLAS E. RAINES;STUART A. FORMAN;KEITH W. MILLER;SYED SHAUKAT HUSAIN;JOSEPH F. COTTEN
分类号 C07D233/58;A61P23/00;C07D233/56 主分类号 C07D233/58
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