发明名称 |
Methods and Compositions for Modifying Apolipoprotein B mRNA Editing |
摘要 |
Products and methods for modifying apolipoprotein B mRNA editing in vivo, reducing serum LDL levels, and treating or preventing an atherogenic disease or disorder are disclosed. Such methods involve the use of a protein including APOBEC-1 or fragments thereof which can edit mRNA encoding apolipoprotein B. The protein including APOBEC-1 can be taken up by cells in the form of a delivery vehicle, such as a liposome or niosome, or directly as a chimeric protein which includes a first polypeptide that includes a protein transduction domain and a second polypeptide that includes APOBEC-1 or a fragment thereof which can edit mRNA encoding apolipoprotein B.
|
申请公布号 |
US2010297219(A1) |
申请公布日期 |
2010.11.25 |
申请号 |
US20100784310 |
申请日期 |
2010.05.20 |
申请人 |
UNIVERSITY OF ROCHESTER MEDICAL CENTER |
发明人 |
SMITH HAROLD C.;YANG YAN;SOWDEN MARK P. |
分类号 |
A61K9/127;C12N15/09;A61K9/06;A61K9/08;A61K9/10;A61K9/14;A61K9/20;A61K9/48;A61K9/70;A61K38/00;A61K38/50;A61K47/48;A61P3/00;A61P3/06;A61P9/10;C07H21/04;C07K14/00;C07K14/155;C07K14/47;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/78;C12N9/96;C12N15/63 |
主分类号 |
A61K9/127 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|