发明名称 |
SINGLE NUCLEOTIDE POLYMORPHISMS ASSOCIATED WITH RENAL DISEASE |
摘要 |
Methods for determining the genetic predisposition of a human subject to developing renal disease, such as focal segmental glomerulosclerosis (FSGS) or end-stage kidney disease are provided herein. These methods include methods for detecting renal disease, or determining the risk of developing renal disease in a human subject, such as a subject of African ancestry. The methods utilize the detection of one or more haplotype blocks comprising at least two tag single nucleotide polymorphisms (SNPs) in a non-coding region of a MYH9 gene or detecting the presence of at least one tag SNP in a non-coding region of a MYH9 gene. An array for detecting a genetic predisposition to renal disease using probes complementary to the tag SNPs in the non-coding region of the MYH9 gene are also disclosed.
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申请公布号 |
US2010297660(A1) |
申请公布日期 |
2010.11.25 |
申请号 |
US20090864218 |
申请日期 |
2009.01.30 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPT OF HEALTH AND HUMAN SERVIECS |
发明人 |
WINKLER CHERYL;NELSON GEORGE;KOPP JEFFREY B.;SMITH MICHAEL W.;JOHNSON RANDALL |
分类号 |
C12Q1/68;C40B40/06 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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