ESTABLISHMENT OF MOTIF COMPRISING ACIDIC AMINO ACID, CAPABLE OF STABILIZING PROTEIN IN CELLS, AND APPLICABLE TO PROTEIN THERAPY, CONTROL OF DIFFERENTIATION/UNDIFFERENTIATION OF CELL AND ANTIBODY THERAPY

摘要

A motif is searched which can inhibit the proteolysis of a protein that has been administered to a cell or an individual. Thus, disclosed is a method for designing/producing a protein having resistance to proteolysis. Specifically disclosed is a motif capable of inhibiting proteolysis, which comprises an amino acid region laying between the 396th position and the 410th position from the C-terminal of DP-1.