Pharmaceutical composition comprising microbubbles for targeted tumor therapy

摘要

The present invention relates to a pharmaceutical composition for the targeted delivery of a pharmaceutically active compound, the composition comprising soft, gas-filled particles having an envelope monolayer comprising one or more surfactants and a pharmaceutically active compound. More particularly, the invention relates to a pharmaceutical composition, wherein the envelope monolayer of the gas-filled particles have a negative overall net charge, and wherein the pharmaceutically active compound has a positive overall net charge and is directly bound to one or more surfactants by both electrostatic and hydrophobic interactions. The present invention also relates to a method of producing said pharmaceutical composition comprising the steps of providing a pharmaceutical active compound- loaded liposomal preparation and the subsequent formation of gas-filled particles by adding a pharmaceutically acceptable gas to the liposomal preparation. Furthermore, the invention relates to the use of said pharmaceutical composition in the treatment of tumors.