| 摘要 |
The invention provides a solution to the above mentioned problem in that it provides a catheter balloon comprising a flexible coating on its outer surface wherein a plurality of microparticles are contained wherein said coating comprises a material selected from the group consisting of poly( N -vinyl-pirrolidone, poly( N -vinyl-pirrolidone-co-butylacrylate), poly(4-vinyl pyridine), polyacrylamides, e.g. poly( N- isopropylacrylamide), poly(amido-amines), poly(ethylene imine), poly(ethylene oxide- block -propylene oxide), poly(ethylene oxide- block -propylene oxide- block -ethylene oxide), poly(styrene-block-isobutylene-block-styrene), poly(hydroxystyrene-block-isobutylene- block -hydroxystyrene), polydialkylsiloxanes, polysaccharides, polyacrylates and polyalkylmethacrylates, e.g. polymethylmethacrylate and poly(2-hydroxyethylmethacrylate) and wherein said microparticles comprise a material selected from the group consisting of polyesters, e.g. poly(lactic acid), poly(lactic-co-glycol acid), poly(glycolic acid), poly(3-hydroxybutyrate), poly(3-hydroxyvalerate), poly(3-hydroxybutyrate-co-3-hydroxyvalerate) and polycaprolactone, polyamides, polysaccharides, polyurethanes, polyalkylmethacrylates and polyacrylates, e.g. polymethylmethacrylate and poly(2-hydroxyethylmethacrylate) and wherein the microparticles comprise a pharmaceutically active compound.
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