发明名称 |
SYNTHETIC PHOSPHODIESTER OLIGONUCLEOTIDES AND THERAPEUTICAL USES THEREOF |
摘要 |
A composition of phosphodiester oligonucleotides of various defined sizes has been created that mimics the effects of defibrotide. The composition essentially consists of mixtures of synthetic phosphodiester oligonucleotides comprising Nmers ranging from 40 mers to 65 mers. The phosphodiester oligonucleotides are preferably heteropolymers composed of either A, G, C, and T at each position but may also be homopolymers, i.e. the same base may be present at each position in the oligonucleotide. These mixtures are effective in the treatment of cancer and other diseases. |
申请公布号 |
EP2252688(A1) |
申请公布日期 |
2010.11.24 |
申请号 |
EP20090721382 |
申请日期 |
2009.03.13 |
申请人 |
GENTIUM S.P.A. |
发明人 |
STEIN, AARON CY;IACOBELLI, MASSIMO |
分类号 |
C12N15/113;A61K31/7088;C12N15/117 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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