发明名称 |
Methods regarding enhanced T-cell receptor-mediated tumor necrosis factor superfamily mRNA expression in peripheral blood leukocytes in patients with crohn's disease |
摘要 |
A method is disclosed for determining whether a human having Crohn's disease is likely to respond to a therapy targeting a TNFSF member or a cytokine by measuring the level of certain mRNAs in response to a stimulus. A method of evaluating the effectiveness of a Crohn's disease therapy in a human is also disclosed. Furthermore, a method of screening compounds for use in the treatment of Crohn's disease is disclosed. A method of monitoring the disease state over time in Crohn's disease patients is also disclosed. |
申请公布号 |
US7838239(B2) |
申请公布日期 |
2010.11.23 |
申请号 |
US20070296425 |
申请日期 |
2007.04.05 |
申请人 |
HITACHI CHEMICAL CO., LTD.;HITACHI CHEMICAL RESEARCH CENTER, INC.;CEDARS-SINAI MEDICAL CENTER |
发明人 |
MITSUHASHI MASATO;TARGAN STEPHAN R. |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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