发明名称 |
Antibody specific for mutant presenilin 2 and method of use thereof |
摘要 |
The present invention describes the identification, isolation, cloning, and determination of the Alzheimer Related Membrane Protein (ARMP) gene on chromosome 14 and a related gene, E5-1, on chromosome 1. Normal and mutant copies of both genes are presented. Transcripts and products of these genes are useful in detecting and diagnosing Alzheimer's disease, developing therapeutics for treatment of Alzheimer's disease, as well as the isolation and manufacture of the protein and the construction of transgenic animals expressing the mutant genes.
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申请公布号 |
US7838247(B2) |
申请公布日期 |
2010.11.23 |
申请号 |
US20070894723 |
申请日期 |
2007.08.20 |
申请人 |
HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP;THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO |
发明人 |
ST. GEORGE-HYSLOP PETER H.;ROMMENS JOHANNA M.;FRASER PAUL E. |
分类号 |
A01K67/027;G01N33/53;A01K67/033;A61K31/70;A61K38/00;A61K38/18;A61K48/00;A61P25/28;C07K14/47;C07K16/18;C07K16/44;C12N5/10;C12N5/20;C12N15/09;C12N15/12;C12N15/85;C12P21/08;C12Q1/68 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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