BIFUNCTIONAL ORGANIC CHIRAL CATALYST COMPOUND WITH SUPERIOR STEREOSELECTIVITY, METHOD FOR PREPARING SAME, AND METHOD FOR PREPARING CHIRAL AMINO ACIDS FROM AZLACTONE USING SAME

摘要

The present invention relates to a method for obtaining chiral amino acid esters having high stereoselectivity from racemic or chiral azlactone, and provides a derivatized bifunctional organic chiral catalyst compound used in the method, and a method for preparing the compound. Conventional preparation methods have the drawbacks of a long reaction period at a low temperature being required to obtain N-acyl amino acid esters having a high enantioselectivity, and the optical selectivity of the obtained compound is not sufficient for industrialization. The catalyst compound according to the present invention can be easily synthesized from cinchona alkaloids. The present invention enables N-acyl amino acid esters having a high enantioselectivity to be obtained in a remarkably economical and simple manner, and enables various (R)-type N-acyl amino acid esters not found in nature to be prepared with high optical purity, and can thus be valuably utilized as a technique for industrialization.