发明名称 |
METHODS OF CHEMICAL SYNTHESIS OF DIAMINOPHENOTHIAZINIUM COMPOUNDS INVOLVING THE USE OF PERSULFATE OXIDANTS |
摘要 |
This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesizing and purifying certain 3,7-diamino- phenothiazin-5-ium compounds (referred to herein as "diaminophenothiazinium compounds") including Methylthioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: a thiosulfonic acid formation (TSAF) as illustrated below, wherein the reaction is carried out in the presence of a thiosulfate and an oxidizing agent that is or comprises persulfate an oxidative coupling (OC); and a ring closure (RC). The resulting compounds and compositions comprising them (e.g., tablets, capsules) are useful in methods of medical treatment and diagnosis, etc., for example, tauopathies, or Alzheimer's disease (AD). |
申请公布号 |
WO2010130977(A1) |
申请公布日期 |
2010.11.18 |
申请号 |
WO2010GB00927 |
申请日期 |
2010.05.11 |
申请人 |
WISTA LABORATORIES LTD.;LARCH, CHRISTOPHER PAUL;STOREY, JOHN MERVYN DAVID;WILLIAMSON, CRAIG;MARSHALL, COLIN;KEMP, STEVEN JOHN |
发明人 |
LARCH, CHRISTOPHER PAUL;STOREY, JOHN MERVYN DAVID;WILLIAMSON, CRAIG;MARSHALL, COLIN;KEMP, STEVEN JOHN |
分类号 |
C07D279/18;A61K31/5415;A61P25/28;C07C381/04 |
主分类号 |
C07D279/18 |
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