发明名称 |
LIGAND OF REGULATING IMMUNE RESPONSE, AND USE THEREOF IN TREATING AN IMMUNE RESPONSE-RELATED DISEASE |
摘要 |
The present invention relates to a ligand to regulate immune response, i.e., PACAP27 which is one of pituitary adenylate cyclase-activating polypeptides and Serum amyloid A (SAA), and their novel use in treating or preventing diseases associated with immune response. More specifically, the present invention relates to a complex of PACAP27-FPRL1 having a regulatory effect on immune response, and a use thereof in regulating immune response. In another aspect, the present invention relates to a complex of SAA and FPRL1, and a use thereof in inhibiting synoviocyte hyperplasia and angiogenesis and treating or preventing inflammatory diseases including Rheumatoid arthritis (RA). |
申请公布号 |
US2010291089(A1) |
申请公布日期 |
2010.11.18 |
申请号 |
US20060993655 |
申请日期 |
2006.07.07 |
申请人 |
POSTECH ACADEMY-INDUSTRY FOUNDATION |
发明人 |
KIM YOUN-DONG;LEE BYOUNG-DAE;KIM YOE-KYUNG;BAE YOE-SIK;LEE TAE-HOON;SUH PANN-GHILL;RYU SUNG-HO |
分类号 |
A61K39/395;A61K31/352;A61K31/5377;A61K31/713;A61K38/08;A61K39/10;A61P9/10;A61P25/28;A61P29/00;A61P35/00;A61P37/02;C07K14/435 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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