Disclosed herein is a fibrous tissue sealant in the form of an anhydrous fibrous sheet comprising a first component which is a fibrous polymer containing electrophilic or nucleophilic groups and a second component capable of crosslinking the first component when the sheet is exposed to an aqueous medium, thereby forming a crosslinked hydrogel that is adhesive to biological tissue. The fibrous tissue sealant may be useful as a general tissue adhesive for medical and veterinary applications such as wound closure, supplementing or replacing sutures or staples in internal surgical procedures, tissue repair, and to prevent post-surgical adhesions. The fibrous tissue sealant may be particularly suitable for use as a hemostatic sealant to stanch bleeding from surgical or traumatic wounds.
申请公布号
WO2010059280(A3)
申请公布日期
2010.11.18
申请号
WO2009US55487
申请日期
2009.08.31
申请人
E. I. DU PONT DE NEMOURS AND COMPANY;DAVID, ARTHUR, SAMUEL;HUANG, TAO;DIMAIO, WILLIAM, GERALD, JR.;KODOKIAN, GEORGE, K.
发明人
DAVID, ARTHUR, SAMUEL;HUANG, TAO;DIMAIO, WILLIAM, GERALD, JR.;KODOKIAN, GEORGE, K.