发明名称 |
Toll-Like Receptor 9 Modulators |
摘要 |
TLR9 is localized to endoplasmic reticulum and upon stimulation with a TLR9 ligand, is transported to a tubular lysosomal compartment as is CpG-DNA. Furthermore, it is shown that TLR9 and CpG-DNA directly bind. It was also found that the MyD88 translocates in response to activation of TLR9-mediated signaling. Methods of identifying compounds that affect translocation and activity of TLR9 and MyD88 are described.
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申请公布号 |
US2010291577(A1) |
申请公布日期 |
2010.11.18 |
申请号 |
US20100787009 |
申请日期 |
2010.05.25 |
申请人 |
UNIVERSITY OF MASSACHUSETTS |
发明人 |
LATZ EICKE;VISINTIN ALBERTO;GOLENBOCK DOUGLAS T. |
分类号 |
C12Q1/68;A61K49/00;C12Q1/00;G01N;G01N33/50;G01N33/53;G01N33/566 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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