发明名称 |
Competitive Regulation of Hepcidin mRNA by Soluble and Cell-Associated Hemojuvelin |
摘要 |
Disclosed herein are hemojuvelin-specific siRNAs that vary hemojuvelin mRNA concentration. Also disclosed herein, GPI-hemojuvelin positively regulated hepcidin mRNA expression, independently of the IL-6 pathway, whereas soluble hemojuvelin (s-hemojuvelin) suppressed hepcidin mRNA expression in primary human hepatocytes in a log-linear dosedependent manner. Disclosed are compositions and methods for modulating diseases of iron metabolism and hepcidin expression or hepcidin levels.
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申请公布号 |
US2010292171(A1) |
申请公布日期 |
2010.11.18 |
申请号 |
US20100775032 |
申请日期 |
2010.05.06 |
申请人 |
GANZ TOMAS;LIN LAN;GOLDBERG YIGAL P |
发明人 |
GANZ TOMAS;LIN LAN;GOLDBERG YIGAL P. |
分类号 |
A61K38/17;A61P3/00;A61P3/02;C07K14/435;C12N5/07;C12N15/63;G01N33/68 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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