摘要 |
Binding members directed to human Fas (Fas), in particular antibody molecules against human Fas, employing the antibody VH and/or VL domain of the antibody molecule termed F45D9, which may be in IgG1 or IgG4 format. Methods of use in patients, diseases or disorders involving apoptosis, such as Graft -Versus -Host Disease, HIV-infection, Stevens- Johnson syndrome or Toxic epidermal necrolysis, Islet transplantation as treatment for insulin-dependent diabetes, diseases based on ischemia or ischemic reperfusion injury, heart disease, renal disease, neurological disorders and injuries and lymphocyte depletion in cancer patients associated to cytotoxic antineoplastic therapy. |
申请人 |
IMED AB;OSORIO, LYDA;RUAN, MAORONG;CHIODI, FRANCESCA;EKRE, HANS-PETER |
发明人 |
OSORIO, LYDA;RUAN, MAORONG;CHIODI, FRANCESCA;EKRE, HANS-PETER |