SAND FLY SALIVARY PROTEINS WITH ANTI-COMPLEMENT ACTIVITY AND METHODS OF THEIR USE

摘要

It has been surprisingly discovered that a sand fly salivary gland polypeptide, or a nucleic acid sequence encoding the polypeptide, can function as an inhibitor of complement activation. The present disclosure provides for methods of treatment of disorders associated with an immune response associated with increased complement activation utilizing compositions comprising the sand fly salivary gland polypeptides of the disclosure. Also provided herein is the use of sand fly salivary gland anti-complement proteins to block transmission of parasites from sand flies to humans and animals.