发明名称 |
COMBINATION THERAPY TO INHIBIT T CELL EFFECTOR FUNCTION |
摘要 |
<p>Methods and compositions are provided for inhibiting the responsiveness of CD4+ T cells that have been sensitized to antigen, i.e. CD4+ memory, or effector T cells. It is shown herein that such effector T cells will fail to proliferate in response to antigen when inhibited by two compounds, which act on two distinct signaling pathways, the mTOR pathway and the MAPK (MEK) pathway. A synergistic combination of inhibitors is required to achieve effector T cell inactivation because a single inhibitor can provide for inactivation of naïve CD4+ T cells, but will not by itself inactivate the sensitized effector T cells.</p> |
申请公布号 |
WO2010132891(A1) |
申请公布日期 |
2010.11.18 |
申请号 |
WO2010US35153 |
申请日期 |
2010.05.17 |
申请人 |
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY;FATHMAN, C. GARRISON;LIN, JACK T. |
发明人 |
FATHMAN, C. GARRISON;LIN, JACK T. |
分类号 |
A01N63/00 |
主分类号 |
A01N63/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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