| 摘要 |
Degradable polymers were synthesized that self-assemble with DNA to form particles that are effective for gene delivery. Small changes to polymer synthesis conditions, particle formulation conditions, and polymer structure provides significant changes to efficacy in a cell-type dependent manner. Polymers presented here are more effective than commercially available materials, such as LIPOFECTAMINE 2000TM, FUGENE®, or polyethylenimine (PEI), for gene delivery to cancerous fibroblasts or human primary fibroblasts. The presently disclosed materials may be useful for cancer therapeutics and regenerative medicine. |
| 申请人 |
THE JOHNS HOPKINS UNIVERSITY;GREEN, JORDAN, J.;SUNSHINE, JOEL, C.;BHISE, NUPURA, S.;SHMUELI, RON, B.;TZENG, STEPHANY, Y. |
发明人 |
GREEN, JORDAN, J.;SUNSHINE, JOEL, C.;BHISE, NUPURA, S.;SHMUELI, RON, B.;TZENG, STEPHANY, Y. |
