COMBINATION THERAPIES AND METHODS USING ANTI-CD3 MODULATING AGENTS AND ANTI-TNF ANTAGONISTS

摘要

This invention relates generally to compositions that contain multiple modulating agents, e.g., multiple modulating agents that target CD3 on T cells and neutralize one or more biological activities of tumor necrosis factor alpha (TNF), such as CD3 modulators including anti-CD3 antibodies and anti-TNF antagonists including anti-TNF antibodies and soluble Fc-fusion receptor proteins, and methods of using these compositions in the treatment, amelioration and/or prevention of relapse of an autoimmune disease.