发明名称 |
COMPOSITIONS AND METHODS FOR MODULATING VASCULAR ENDOTHELIAL GROWTH FACTOR C (VEGF-C) EXPRESSION |
摘要 |
The present invention relates to compounds and methods for inhibiting the expression of vascular endothelial growth factor-C (VEGF-C) in a target cell. Particularly, the present invention relates to antisense polynucleotides complementary to a lens epithelium-derived growth factor (LEDGF/p75) mRNA and uses thereof for inhibiting tumor progression and tumor metastasis. The present invention further relates to uses of LEDGF/p75 polypeptide or a nucleic acid encoding same for treating endothelial cell related conditions, particularly inflammation and edema. |
申请公布号 |
US2010291036(A1) |
申请公布日期 |
2010.11.18 |
申请号 |
US20090812735 |
申请日期 |
2009.01.25 |
申请人 |
YEDA RESEARCH AND DEVELOPMENT CO.LTD, AT THE WEIZMANN INSTITUTE OF SCIENCE |
发明人 |
NEEMAN MICHAL;COHEN BATYA;SAPOZNIK STAV;BEN-DOR SHIFRA;MEIR GILA |
分类号 |
A61K35/00;A61K31/7088;A61K38/18;A61P17/02;A61P29/00;A61P31/00;A61P35/00;A61P37/02;C07H21/00;C12N15/113 |
主分类号 |
A61K35/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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