发明名称 |
MOLECULAR ENHANCEMENT OF EXTRACELLULAR MATRIX AND METHODS OF USE |
摘要 |
<p>A composition comprising a human- or animal-derived extracellular matrix and a macromolecular network which is prepared ex vivo is provided that is useful in the repair of a tissue injury, particularly in repair of tears or gaps between a tendon and a bone, such as in a rotator cuff tear. In an embodiment, the composition comprises a human- or animal-derived extracellular matrix having impregnated therein a macromolecular network of hyaluronan macromolecules that have been cross-linked via dihydroxyphenyl linkages, so that the cross-linked network is interlocked within the extracellular matrix. The resulting HA-incorporated extracellular matrix can be supplied in the form of a patch to reinforce a tissue repair or cover a tissue defect.</p> |
申请公布号 |
EP2249891(A2) |
申请公布日期 |
2010.11.17 |
申请号 |
EP20090710120 |
申请日期 |
2009.02.13 |
申请人 |
THE CLEVELAND CLINIC FOUNDATION |
发明人 |
DERWIN, KATHLEEN, ANNE;IANNOTTI, JOSEPH, PATRICK;CHIN, LIKANG;CALABRO, ANTHONY |
分类号 |
A61F2/08;A61L27/36;A61L27/48 |
主分类号 |
A61F2/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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