发明名称 |
COMPOSITION INHIBITING THE EXPRESSION OF TARGET GENE IN EYEBALL AND REMEDY FOR DISEASE IN EYEBALL |
摘要 |
There is provided a composition comprising an RNA-encapsulated liposome, the RNA comprising a sequence being of 15 to 30 contiguous nucleotides of mRNA of a target gene associated with a disease in an eyeball, and a sequence complementary to the sequence, wherein the liposome is capable of reaching an eyeball, and the like. The liposome in which an RNA is encapsulated is, for example, a liposome composing a complex particle comprising a lead particle and the RNA as constituent components, the lead particle comprising a cationic lipid, and a bilayer lipid membrane for coating the complex particle. The bilayer lipid membrane is a bilayer lipid membrane comprising a neutral lipid, and a lipid derivative, a fatty acid derivative or an aliphatic hydrocarbon derivative of a water-soluble substance as constituent components. |
申请公布号 |
EP1970078(A4) |
申请公布日期 |
2010.11.17 |
申请号 |
EP20070706535 |
申请日期 |
2007.01.10 |
申请人 |
KYOWA HAKKO KIRIN CO., LTD.;THE UNIVERSITY OF TOKYO |
发明人 |
YAGI, NOBUHIRO;YAMAUCHI, MASAHIRO;AOKI, NOBORU;TAMAKI, YASUHIRO;TAKAHASHI, HIDENORI;IRIYAMA, AYA;NAGAI, RYOZO;MANABE, ICHIRO |
分类号 |
C12N15/11;A61K9/127;A61K31/7105;A61K47/44;A61K48/00;A61P27/02 |
主分类号 |
C12N15/11 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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