发明名称 Dual-acting antihypertensive agents
摘要 The invention relates to compounds having the formula: wherein: Ar, r, R3, Z, X, and R5-7 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
申请公布号 US7834041(B2) 申请公布日期 2010.11.16
申请号 US20080231858 申请日期 2008.09.05
申请人 THERAVANCE, INC. 发明人 CHOI SEOK-KI;FATHEREE PAUL R.;GENDRON ROLAND;HUDSON RYAN;MCKINNELL ROBERT MURRAY;SASIKUMAR VIVEK
分类号 A61K31/41;C07D257/04 主分类号 A61K31/41
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