发明名称 |
HERSTELLUNG VON 2-SUBSTITUIERTEN 4-CHLOR-5- FORMYLIMIDAZOLEN DURCH VILSMEIER-REAKTION DES KONDENSATIONSPRODUKTS VON GLYCIN UND EINEM IMIDOESTER MIT EINEM FORMAMID IN GEGENWART EINES TRIFLAT- (TRIFLUORMETHANSULFONAT-) KATALYSATORS |
摘要 |
The invention relates to a preparation process for 2-substituted 5-formylimidazoles, wherein the intermediate high-pressurized synthesis of an 2-substituted 4-hydroxymethylimidazole as known in the art is conveniently avoided, and wherein much higher yields are obtained. Instead, it is proposed to prepare such 2-substituted 5-formylimidazoles via a one-pot synthesis involving 2-substituted 4-chloro-5-formylimidazole, thereby employing an additional hydrodehalogenation step. Moreover, it is found that the yield and purity of 2-substituted 4-chloro-5-formylimidazole itself can be significantly improved using a triflate catalyst in the preparation process. |
申请公布号 |
AT485278(T) |
申请公布日期 |
2010.11.15 |
申请号 |
AT20060733056T |
申请日期 |
2006.04.07 |
申请人 |
DISHMAN PHARMACEUTICALS AND CHEMICALS LTD. |
发明人 |
RAJNIKANT VYAS, JANMEJAY;SATYA VARMA NIDADAVOLU, VENKATA;PRAKASH SINGH, ANAND |
分类号 |
C07D233/68;C07D233/54 |
主分类号 |
C07D233/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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