发明名称 |
GEN DES TRANSKRIPTIONSFAKTORS ARNTL2 SOWIE BEI DER DIAGNOSE, VORBEUGUNG UND BEHANDLUNG VON TYP-1-DIABETES VERWENDETE EXPRESSIONSPRODUKTE DAVON |
摘要 |
The present application identifies the involvement of the HIFbeta-homologous Arntl2 gene in the control of type 1 (insulin-dependent) diabetes. Accordingly, the present invention provides a method of determining the susceptibility of a subject to developing insulin-dependent diabetes based on the expressing level of the Arntl2 gene. The present invention also provides a method for identifying compounds effective for treating or preventing insulin-dependent diabetes in a subject in need thereof and a method of treating or preventing insulin-dependent diabetes by administering an effective amount of compound identified by the identification method. The present invention also provides a method of enhancing protection against insulitis progression or autoimmune diabetes development in a subject in need thereof comprising, enhancing expression of the Arntl2 gene or modulating the expression of target genes thereof. |
申请公布号 |
AT485399(T) |
申请公布日期 |
2010.11.15 |
申请号 |
AT20070734854T |
申请日期 |
2007.02.27 |
申请人 |
INSTITUT PASTEUR |
发明人 |
AVNER, PHILIP;ROGNER, UTE;HUNG, MING-SHIU |
分类号 |
C12Q1/68;G01N33/50 |
主分类号 |
C12Q1/68 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|