PROCESSES FOR PREPARING BIARYL BORONIC ACIDS AND N-PROTECTED N-(3-METHOXY-5-METHYLPYRAZIN-2-YL)-2-(4-[1,3,4-OXADIAZOL-2-YL]PHENYL)PYRIDINE-3-SULPHONAMIDE

摘要

IMPROVED CHEMICAL PROCESSES FOR PREPARING INTERMEDIATES OF FORMULA I AND IV: ARE DESCRIBED. CERTAIN OF THESE INTERMEDIATES ARE USEFUL IN THE MANUFACTURE OF COMPOUNDS WHICH ARE USEFUL IN THE TREATMENT OF, FOR EXAMPLE, CANCER, PAIN AND CARDIOVASCULAR DISEASES IN A WARM-BLOODED ANIMAL SUCH AS MAN, PARTICULARLY COMPOUNDS WHICH POSSESS ENDOTHELIN RECEPTOR ANTAGONIST ACTIVITY.