| 摘要 |
The current invention concerns new bioadhesive polymers incorporated with biodegradable components. The bioadhesive components used are polycarboxylic acids, while the biodegradable components can be any synthetic degradable polymers, particularly biodegradable polyesters whose degradation products are small molecular esters. The two polymer components may be covalently bound to each forming graft, block or random copolymers, examples of which include poly(acrylic acid)-graft-poly(lactic acid) (PAA-g-PLA) and pol(lactic-co-glycolic acid)-g-poly(acrylic acid) (PLGA-g-PAA). The two components may also be incorporated into one material by forming non-covalent interpolymer complex via, for examples, hydrogen bonding, ionic bonding or hydrophobic bonding. Typical examples in this category include the hydrogen bonding interpolymer complex formed between poly(methacrylic acid) and poly(lactic acid)-b-poly(ethylene glycol)-b-poly(lactic acid) tri-block copolymers. The new materials may be used without a treatment agent to provide a lasting acidic pH environment or used with a treatment agent as a delivery system. |
