发明名称 |
METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCERS AND PATHOGENIC INFECTIONS |
摘要 |
The subject application provides small compounds that are able to suppress autophagy in various cells. These compounds are useful in augmenting the existing treatments of various cancers and microbial/parasitic infections. Thus, the subject application also provides methods of treating various types of cancers and microbial/parasitic infections. Also provided by the subject application are methods of suppressing the expansion of autophagosomes within cells or individuals and inhibiting the lipidation of autophagy-related protein 8 (Atg8).
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申请公布号 |
US2010285012(A1) |
申请公布日期 |
2010.11.11 |
申请号 |
US20090811646 |
申请日期 |
2009.01.05 |
申请人 |
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION INC. |
发明人 |
DUNN, JR. WILLIAM A.;AKIN DEBRA E.;PROGULSKE-FOX ANN;OSTROV DAVID A. |
分类号 |
A61K39/395;A61K31/285;A61K31/397;A61K31/427;A61K31/43;A61K31/431;A61K31/437;A61K31/44;A61K31/444;A61K31/454;A61K31/4704;A61K31/4738;A61K31/496;A61K31/506;A61K31/513;A61K31/517;A61K31/5383;A61K31/541;A61K31/546;A61K31/65;A61K31/7048;A61K33/24;A61K38/16;A61K38/18;A61P31/04;A61P33/00;A61P35/00 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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