发明名称 |
Compositions and methods for inhibiting expression of Eg5 gene |
摘要 |
<p>The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Eg5 gene (Eg5 gene), comprising an antisense strand having a nucleotide sequence which is less than 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the Eg5 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by Eg5 expression and the expression of the Eg5 gene using the pharmaceutical composition; and methods for inhibiting the expression of the Eg5 gene in a cell.</p> |
申请公布号 |
AU2010235872(A1) |
申请公布日期 |
2010.11.11 |
申请号 |
AU20100235872 |
申请日期 |
2010.10.15 |
申请人 |
ALNYLAM PHARMACEUTICALS, INC. |
发明人 |
ANKE GEICK;DAVID BUMCROT;HANS-PETER VORNLOCHER;PAMELA TAN |
分类号 |
A01N43/04;A61K31/70;C07H21/02;C07H21/04;C12N15/113 |
主分类号 |
A01N43/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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