发明名称 |
COMPOSITIONS AND METHODS FOR THE DELIVERY OF OXYGEN |
摘要 |
H-NOX proteins are mutated to exhibit improved or optimal kinetic and thermodynamic properties for blood gas O2 delivery. The engineered H-NOX proteins comprise mutations that impart altered O2 or NO ligand-binding relative to the corresponding wild-type H-NOX domain, and are operative as physiologically compatible mammalian blood O2 gas carriers. The invention also provides pharmaceutical compositions, kits, and methods that use wild-type or mutant H-NOX proteins for the treatment of any condition for which delivery of O2 is beneficial.
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申请公布号 |
US2010285104(A1) |
申请公布日期 |
2010.11.11 |
申请号 |
US20070302002 |
申请日期 |
2007.05.21 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
CARY STEPHEN P. L.;BOON ELIZABETH M.;WEINERT EMILY;WINGER JONATHAN A.;MARLETTA MICHAEL A. |
分类号 |
A61K9/127;A61K38/00;C07H21/04;C07K14/195;C07K14/435;C12N5/02;C12N5/10;C12N15/63;C12P21/06;G01N31/00 |
主分类号 |
A61K9/127 |
代理机构 |
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主权项 |
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地址 |
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