MODULATION OF INDUCIBLE NITRIC OXIDE (INOS) BINDING TO SPRY DOMAIN-CONTAINING SOCS-BOX PEPTIDES (SSB)
摘要
<p>The present invention relates to methods of modulating the level of inducible nitric oxide synthase (iNOS) in a cell which comprises administering to the cell a compound which modulates binding of SPRY domain-containing SOCS box protein (SSB) to iNOS, and/or a compound which modulates SSB activity in the cell. Further provided are methods of treating or preventing disease in a subject by modulating the level of iNOS in a cell, as well as compounds which modulate binding of SSB to iNOS and compounds which modulate SSB activity.</p>
申请公布号
WO2010127400(A1)
申请公布日期
2010.11.11
申请号
WO2010AU00525
申请日期
2010.05.06
申请人
WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH;KOLESNIK, TATIANA;KUANG, ZHIHE;LEWIS, ROWENA SUE;NICHOLSON, SANDRA ELAINE;NORTON, RAY
发明人
KOLESNIK, TATIANA;KUANG, ZHIHE;LEWIS, ROWENA SUE;NICHOLSON, SANDRA ELAINE;NORTON, RAY