发明名称 |
A NANO-EMULSION INJECTION OF VINCA ALKALOIDS AND THE PREPARATION METHOD THEREOF |
摘要 |
<p>A nano-emulsion injection of Vinca alkaloids and its preparation method are disclosed. The injection is an oil-in-water emulsion injection comprising Vinca alkaloids or their salts, injectable oil, surfactant(s) and injectable water, wherein the average diameter of the droplets of the emulsion is less than 100 nm and the pH of the emulsion is 7-9. The preparation method comprises the steps of preparing the oil phase and the aqueous phase respectively, homogeneously mixing the oil phase and the aqueous phase with high speed, adding the active ingredient, adjusting the pH to 7-9, adding water to constant volume, and homogenizing the emulsion till the average diameter of the droplets being less than 100 nm. The alternative method comprises the steps of homogeneously mixing the oil phase and the aqueous phase, homogenizing the obtained emulsion under high pressure till the average diameter of the droplets being less than 100 nm, adding the active ingredient, adjusting the pH to 7-9, stirring, and adding water to constant volume.</p> |
申请公布号 |
WO2010127541(A1) |
申请公布日期 |
2010.11.11 |
申请号 |
WO2009CN75409 |
申请日期 |
2009.12.08 |
申请人 |
JIANGSU HENGRUI MEDICINE CO., LTD.;SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.;TONG, XINYONG;WANG, HAIFENG;CUI, SHUANGJIN;YU, LI |
发明人 |
TONG, XINYONG;WANG, HAIFENG;CUI, SHUANGJIN;YU, LI |
分类号 |
A61K9/107;A61K31/475;A61P35/00 |
主分类号 |
A61K9/107 |
代理机构 |
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