METHOD FOR THE DETERMINATION OF P BLOOD GROUPS

摘要

The invention relates to a method to discriminate between the P 1 and P 2 blood group alleles by the use of at least one nucleotide sequence being identical/homologous to at least part of the nucleotide sequences as shown in SEQ ID NO:1-6 or a nucleotide sequence showing at least 90% identity to any of SEQ ID NO:1-6 and wherein the difference is a cytosine (C) or thymidine (T) in position 129 as shown in SEQ ID NO:1, wherein C/C or C/T in the two alleles gives rise to the P1 phenotype and T/T to the P2 phenotype. Furthermore, zygosity for the P 1 allele (i.e. C/C vs. C/T) also predicts the P1 and Pk antigen levels on human cells. The invention also relates to means to be used in said method including primers, probes and markers.