发明名称 |
COMBINATION THERAPY FOR THE TREATMENT OF DIABETES AND CONDITIONS RELATED THERETO AND FOR THE TREATMENT OF CONDITIONS AMELIORATED BY INCREASING A BLOOD GLP-1 LEVEL |
摘要 |
The present invention concerns combination of an amount of a GPR119 agonist with an amount of a dipeptidyl peptidase IV (DPP-IV) inhibitor such that the combination provides an effect in lowering a blood glucose level or in increasing a blood GLP-1 level in a subject over that provided by the amount of the GPR119 agonist or the amount of the DPP-IV inhibitor alone and the use of such a combination for treating or preventing diabetes and conditions related thereto or conditions ameliorated by increasing a blood GLP-1 level. The present invention also relates to the use of a G protein-coupled receptor to screen for GLP-1 secretagogues.
|
申请公布号 |
US2010285495(A1) |
申请公布日期 |
2010.11.11 |
申请号 |
US20090610674 |
申请日期 |
2009.11.02 |
申请人 |
ARENA PHARMACEUTICALS, INC. |
发明人 |
CHU ZHI-LIANG;LEONARD JAMES N.;AL-SHAMMA HUSSIEN A.;JONES ROBERT M. |
分类号 |
G01N33/53 |
主分类号 |
G01N33/53 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|